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KMID : 1059519940380070516
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Journal of the Korean Chemical Society
1994 Volume.38 No. 7 p.516 ~ p.520
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Synthesis of Peptides Containing Optically Active 2-Amino-3-Phosphonopropionic Acid
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Kim Sang-Bum
Cho Sung-Ki
Han Jeong-Sik
Kim Yong-Joon
Hong Suk-In
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Abstract
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New synthetic method of optically active 2-amino-3-phosphonopropionic acid from L-serine was developed and their phosphonotripeptides, phthalylglycylglycyl-2-amino-3-(diethylphosphono)-propionic acid methyl ester and phthalylglycyl-L-phenylalanyl-2-amino-3-(diethylphosphono)propionic acid methyl ester, were synthesized by coupling reaction of amino acids with 2-amino-3-phosphonopropionic acid methyl ester.
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